2 September 2009 OCT monitoring of diffusion of clearing agents within tooth dentin
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Abstract
Monitoring of agent diffusion within tooth tissues is important in a wide context of tooth therapy (diffusion of medicinal preparations) and cosmetics (chemical whitening agents). We report here the results of optical coherence tomography (OCT) monitoring of diffusion of water and glycerol as clearing agents in samples of human tooth tissue. The diffusion process is analyzed by monitoring the changes in the OCT signal slope and the depth-resolved amplitude of OCT signal from a sample. Slow temporal kinetics of the mean attenuation coefficient was measured to monitor a saturable optical clearing due to the diffusion of the agent. The average permeability coefficient was estimated by dividing the measured thickness of the selected region by the time it took for the agent to diffuse through. The experimental results demonstrate that OCT can be an efficient tool in the study of agent diffusion through hard tissues.
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N. A. Trunina, N. A. Trunina, V. V. Lychagov, V. V. Lychagov, V. V. Tuchin, V. V. Tuchin, } "OCT monitoring of diffusion of clearing agents within tooth dentin", Proc. SPIE 7443, Applications of Digital Image Processing XXXII, 74432D (2 September 2009); doi: 10.1117/12.828646; https://doi.org/10.1117/12.828646
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