4 September 2009 Sparse algebraic reconstruction for fluorescence mediated tomography
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Abstract
In this paper, we explore the use of anatomical information as a guide in the image formation process of fluorescence molecular tomography (FMT). Namely, anatomical knowledge obtained from high resolution computed tomography (micro-CT) is used to construct a model for the diffusion of light and to constrain the reconstruction to areas candidate to contain fluorescent volumes. Moreover, a sparse regularization term is added to the state-of-the-art least square solution to contribute to the sparsity of the localization. We present results showing the increase in accuracy of the combined system over conventional FMT, for a simulated experiment of lung cancer detection in mice.
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Arrate Muñoz-Barrutia, Arrate Muñoz-Barrutia, Carlos Pardo-Martin, Carlos Pardo-Martin, Thomas Pengo, Thomas Pengo, Carlos Ortiz-de-Solorzano, Carlos Ortiz-de-Solorzano, } "Sparse algebraic reconstruction for fluorescence mediated tomography", Proc. SPIE 7446, Wavelets XIII, 744604 (4 September 2009); doi: 10.1117/12.824456; https://doi.org/10.1117/12.824456
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