20 October 2009 Fabrication, characterization and in-vitro cytotoxicity of magnetic nanocomposite polymeric film for multi-functional medical application
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Proceedings Volume 7493, Second International Conference on Smart Materials and Nanotechnology in Engineering; 74934E (2009) https://doi.org/10.1117/12.841207
Event: Second International Conference on Smart Materials and Nanotechnology in Engineering, 2009, Weihai, China
Abstract
Cancer comprehensive treatment has been fully acknowledged as it can provide an effective multimodality approach for fighting cancers. In this study, various innovative technologies for cancer treatment including cancer nanotechnology, chemotherapy by sustainable release, as well as magnetic induction hyperthermia (MIH) have been integrated for the purpose of cancer comprehensive treatment. Briefly, such kind of treatment can be realized by applying of the tailored magnetic nanoparticles (MNPs) composite polymeric film. Fe3O4 MNPs acting as the agent for MIH, and anti-cancer drug docetaxel as chemotherapeutic agent were incorporated within the biodegradable polymeric film. Physiochemical characterizations on MNPs and the film have been systematically carried out by various instrumental analyses. Our results demonstrated that the film has been successfully fabricated by the solvent cast method. Hyperthermia could be induced by stimulating the nanocomposite film under an alternative magnetic field (AMF). The incorporation of MNPs, as well as hyperthermia would facilitate the drug release from the polymeric film. The in-vitro cytotoxicity results indicated the bi-modal cancer treatment approach for combined MIH and chemotherapy is more effective than the mono-modal treatment by docetaxel treatment. The magnetic nanocomposite film can realize cancer comprehensive treatment thus has great potential in clinical application.
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Lingyun Zhao, Lingyun Zhao, Xiaoyu Xu, Xiaoyu Xu, Xiaowen Wang, Xiaowen Wang, Xiaodong Zhang, Xiaodong Zhang, Fuping Gao, Fuping Gao, Jintian Tang, Jintian Tang, } "Fabrication, characterization and in-vitro cytotoxicity of magnetic nanocomposite polymeric film for multi-functional medical application", Proc. SPIE 7493, Second International Conference on Smart Materials and Nanotechnology in Engineering, 74934E (20 October 2009); doi: 10.1117/12.841207; https://doi.org/10.1117/12.841207
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