A novel cancer-targeting transporter with integrin alphavbeta3 monoclonal antibody functionalized single-walled carbon nanotubes

Zhongmin Ou; Baoyan Wu; Da Xing

doi:10.1117/12.843468

28 October 2009 A novel cancer-targeting transporter with integrin α_vβ₃ monoclonal antibody functionalized single-walled carbon nanotubes

Zhongmin Ou, Baoyan Wu, Da Xing

Author Affiliations +

Proceedings Volume 7519, Eighth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2009); 751904 (2009) https://doi.org/10.1117/12.843468
Event: Photonics and Optoelectronics Meetings 2009, 2009, Wuhan, China

Abstract

The pursuit of efficient and highly targeting-selective transporters is an active topic in cancer-targeting therapy. In this study, a novel cancer-targeting transporter with integrin α_vβ₃ monoclonal antibody functionalized single-walled carbon nanotubes (SWCNTs) was developed to investigate cancer cell targeting in vitro. SWCNTs were first modified by phospholipid-bearing polyethylene glycol (PL-PEG). PL-PEG functionalized SWCNTs were then conjugated with fluorescein isothiocyanate (FITC) labeled integrin α_vβ₃ monoclonal antibody to construct SWCNT-integrin α_vβ₃ monoclonal antibody system (denoted as SWCNT-PEG-mAb). In vitro study revealed that the system had a high efficiency in cancer cell targeting in integrin α_vβ₃ positive U87MG cells. Moreover, the SWCNT-PEG-mAb is stable in physiological media, and can be readily transported into U87MG cells via integrin α_vβ₃-mediated endocytosis in cell. In summary, the integrin α_vβ₃ monoclonal antibody labeled SWCNT is a potential carrier-candidate for cancer-imaging and drug-delivering in cancer-targeting therapy.

Citation Download Citation

Zhongmin Ou, Baoyan Wu, and Da Xing "A novel cancer-targeting transporter with integrin α_vβ₃ monoclonal antibody functionalized single-walled carbon nanotubes", Proc. SPIE 7519, Eighth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2009), 751904 (28 October 2009); https://doi.org/10.1117/12.843468

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