28 October 2009 Collagen remodeling in photo-thermal damaged skin with optical coherence tomography and multiphoton microscopy
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Abstract
Cutaneous photo-thermal damage is the common damages in clinical medicine; it is a complex and dynamic process that follows an orderly sequence of events. The sequence can be roughly divided into three distinct, yet sequentially overlapping phases-inflammation, granulation tissue formation, and tissue remodeling. Characteristic structural changes associated with each phase could provide a basis for photo-thermal damage assessment with imaging technologies. Monitoring the skin tissue response during the skin after irradiated by laser and tracing the process of skin remodeling would help to understand the mechanism of photo-thermal. Optical coherence tomography (OCT) and multiphoton microscopy (MPM) imaging were used to observe the process of the collagen remodeling in mouse dermis photo-thermal injured which after irradiated by intense pulsed light source (IPLs) in this paper. Our finding showed that the OCT and MPM techniques can image the process of collagen remodeling in mouse dermis.
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Shu-lian Wu, Shu-lian Wu, Hui Li, Hui Li, Xiao-man Zhang, Xiao-man Zhang, Lili Yu, Lili Yu, } "Collagen remodeling in photo-thermal damaged skin with optical coherence tomography and multiphoton microscopy", Proc. SPIE 7519, Eighth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2009), 75190B (28 October 2009); doi: 10.1117/12.841617; https://doi.org/10.1117/12.841617
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