28 October 2009 Novel nano drug delivery systems for hepatic tumor
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The adriamycin and galactose was grafted to dextran. The novel nanopartcile drug delivery system (DDS) was prepared from the chemical modified polysaccharide by the dialysis. The content of the ADR moiety in the polymeric-drug conjugate was about 2 mol%. The size and morphology of prepared nanoparticles were characterized using dynamic light scattering and transmission electron microscope. The results showed that the nanoparticles were spherical and their size was less than 200 nm. In vitro cytotoxicity of the nanoparticles was tested by the MTT assay. The nano DDS has similar cytotoxicity as free adriamycin for incubation with HepG2 cells. In contrast, for the incubation with Hela cells of the DDS, there was no signicant cytotoxicity change.
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Yu Cao, Yu Cao, Jing Liu, Jing Liu, Hong Ma, Hong Ma, Jing Bai, Jing Bai, Chao Qi, Chao Qi, "Novel nano drug delivery systems for hepatic tumor", Proc. SPIE 7519, Eighth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2009), 751912 (28 October 2009); doi: 10.1117/12.844928; https://doi.org/10.1117/12.844928

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