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28 October 2009 Pathological process investigation of Jadassohn-Pellizzari anetoderma based on multiphoton microscopy
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Multiphoton microscopy based on two-photon excited fluorescence (TPEF) and second harmonic generation (SHG) was firstly employed to investigate pathological process from the unaffected skin to the erythematous phase and to finally affected skin of Jadassohn-Pellizzari anetoderma. Our study showed that the normal elastic fibers in unaffected skin were almost completely absent in erthematous skin tissue, then replaced by a lot of elastic fibers with granular morphology in affected skin. The obvious change of collagen fibers and occurrence of inflammatory cell infiltration in erthematous tissue suggested that variation of these two components were also main pathogenesis of anetoderma except for deficiency of elastic fibers. Our results give a sight to noninvasively study the pathological process of skin disease and the other disease with tight relation to variation of collagen and elastic fibers in skin dermis and cell in skin epidermis.
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Jianxin Chen, Jingjun Zhao, Yinghong Yang, Shuangmu Zhuo, Xingshan Jiang, Wei Tian, Xiaoyin Ye, and Lihang Lin "Pathological process investigation of Jadassohn-Pellizzari anetoderma based on multiphoton microscopy", Proc. SPIE 7519, Eighth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2009), 751914 (28 October 2009);

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