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11 February 2010 The measurement of hemoglobin oxygen saturation using multiwavelength photoacoustic microscopy
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Abstract
Hemoglobin oxygen saturation (SO2) is one of the most critical functional parameters to the metabolism. In this paper, we mainly introduced some initial results of measuring blood oxygen using multi-wavelength photoacoustic microscopy (PAM). In phantom study, we demonstrate the photoacoustic signal amplitude increases linearly with the concentration of red or blue ink. Then the calculated concentration of red ink in double-ink mixtures with PAM has a 5% difference with the result measured with spectrophotometric analysis. In ex vivo experiment, the measured result exhibt 15% difference between the PAM and spectrophotometric analysis. Experiment results suggest that PAM could be used to determine the SO2 quantitatively.
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Zilin Deng, Xiaoquan Yang, Lejun Yu, and Hui Gong "The measurement of hemoglobin oxygen saturation using multiwavelength photoacoustic microscopy", Proc. SPIE 7547, Saratov Fall Meeting 2009: International School for Junior Scientists and Students on Optics, Laser Physics, and Biophotonics, 75470C (11 February 2010); https://doi.org/10.1117/12.853222
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