2 March 2010 Comparison between two time-resolved approaches for prostate cancer diagnosis: high rate imager vs. photon counting system
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Proceedings Volume 7548, Photonic Therapeutics and Diagnostics VI; 75481A (2010) https://doi.org/10.1117/12.841125
Event: SPIE BiOS, 2010, San Francisco, California, United States
Abstract
Finding a way to combine ultrasound and fluorescence optical imaging on an endorectal probe may improve early detection of prostate cancer. A trans-rectal probe adapted to fluorescence diffuse optical tomography measurements was developed by our team. This probe is based on a pulsed NIR laser source, an optical fiber network and a time-resolved detection system. A reconstruction algorithm was used to help locate and quantify fluorescent prostate tumors. In this study, two different kinds of time-resolved detectors are compared: High Rate Imaging system (HRI) and a photon counting system. The HRI is based on an intensified multichannel plate and a CCD Camera. The temporal resolution is obtained through a gating of the HRI. Despite a low temporal resolution (300ps), this system allows a simultaneous acquisition of the signal from a large number of detection fibers. In the photon counting setup, 4 photomultipliers are connected to a Time Correlated Single Photon Counting (TCSPC) board, providing a better temporal resolution (0.1 ps) at the expense of a limited number of detection fibers (4). At last, we show that the limited number of detection fibers of the photon counting setup is enough for a good localization and dramatically improves the overall acquisition time. The photon counting approach is then validated through the localization of fluorescent inclusions in a prostate-mimicking phantom.
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J. Boutet, M. Debourdeau, A. Laidevant, L. Hervé, J.-M. Dinten, "Comparison between two time-resolved approaches for prostate cancer diagnosis: high rate imager vs. photon counting system", Proc. SPIE 7548, Photonic Therapeutics and Diagnostics VI, 75481A (2 March 2010); doi: 10.1117/12.841125; https://doi.org/10.1117/12.841125
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