2 March 2010 Comparison between two time-resolved approaches for prostate cancer diagnosis: high rate imager vs. photon counting system
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Proceedings Volume 7548, Photonic Therapeutics and Diagnostics VI; 75481A (2010) https://doi.org/10.1117/12.841125
Event: SPIE BiOS, 2010, San Francisco, California, United States
Abstract
Finding a way to combine ultrasound and fluorescence optical imaging on an endorectal probe may improve early detection of prostate cancer. A trans-rectal probe adapted to fluorescence diffuse optical tomography measurements was developed by our team. This probe is based on a pulsed NIR laser source, an optical fiber network and a time-resolved detection system. A reconstruction algorithm was used to help locate and quantify fluorescent prostate tumors. In this study, two different kinds of time-resolved detectors are compared: High Rate Imaging system (HRI) and a photon counting system. The HRI is based on an intensified multichannel plate and a CCD Camera. The temporal resolution is obtained through a gating of the HRI. Despite a low temporal resolution (300ps), this system allows a simultaneous acquisition of the signal from a large number of detection fibers. In the photon counting setup, 4 photomultipliers are connected to a Time Correlated Single Photon Counting (TCSPC) board, providing a better temporal resolution (0.1 ps) at the expense of a limited number of detection fibers (4). At last, we show that the limited number of detection fibers of the photon counting setup is enough for a good localization and dramatically improves the overall acquisition time. The photon counting approach is then validated through the localization of fluorescent inclusions in a prostate-mimicking phantom.
© (2010) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
J. Boutet, J. Boutet, M. Debourdeau, M. Debourdeau, A. Laidevant, A. Laidevant, L. Hervé, L. Hervé, J.-M. Dinten, J.-M. Dinten, } "Comparison between two time-resolved approaches for prostate cancer diagnosis: high rate imager vs. photon counting system", Proc. SPIE 7548, Photonic Therapeutics and Diagnostics VI, 75481A (2 March 2010); doi: 10.1117/12.841125; https://doi.org/10.1117/12.841125
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