Use of an optical clearing agent during noninvasive laser coagulation of the canine vas deferens, ex vivo and in vivo

Christopher M. Cilip; Ashley E. Ross; Jonathan P. Jarow; Nathaniel M. Fried

doi:10.1117/12.840915

2 March 2010 Use of an optical clearing agent during noninvasive laser coagulation of the canine vas deferens, ex vivo and in vivo

Christopher M. Cilip, Ashley E. Ross, Jonathan P. Jarow, Nathaniel M. Fried

Author Affiliations +

Proceedings Volume 7548, Photonic Therapeutics and Diagnostics VI; 75481C (2010) https://doi.org/10.1117/12.840915
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

Development of a noninvasive vasectomy technique may eliminate male fear of complications and result in a more popular procedure. This study explores application of an optical clearing agent (OCA) to the scrotal skin to reduce both the laser power necessary for successful noninvasive laser vasectomy and the probability of scrotal skin burns. A mixture of DMSO/glycerol was noninvasively delivered into the scrotal skin using a Madajet. Near-infrared laser radiation with a range of average powers (7.0-11.7 W) was delivered in conjunction with a range of cryogen spray cooling rates (0.20-0.33 Hz) to the skin surface in a canine model, ex vivo and in vivo. Burst pressure (BP) measurements were conducted to quantify the strength of vas closure. A 30-min application of the OCA improved skin transparency by 26 ± 5 %, reducing the average power necessary for successful noninvasive laser vasectomy from 9.2 W without OCA (BP = 291 ± 31 mmHg) to 7.0 W with OCA (BP = 292 ± 19 mmHg). Control studies without OCA at 7.0 W failed to coagulate the vas with burst pressures (82 ± 28 mmHg) significantly below typical ejaculation pressures (136 ± 29 mmHg). Application of an optical clearing agent reduced the laser power necessary for successful noninvasive thermal coagulation of the vas by approximately 25%. This technique may result in the use of a less expensive laser system and eliminate the formation of scrotal skin burns during the procedure.

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Christopher M. Cilip, Ashley E. Ross, Jonathan P. Jarow, and Nathaniel M. Fried "Use of an optical clearing agent during noninvasive laser coagulation of the canine vas deferens, ex vivo and in vivo", Proc. SPIE 7548, Photonic Therapeutics and Diagnostics VI, 75481C (2 March 2010); https://doi.org/10.1117/12.840915

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KEYWORDS

Skin

Optical clearing

In vivo imaging

Cryogenics

Tissues

Transparency

Fiber lasers

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