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4 March 2010Dynamic differential imaging of intrinsic optical responses in the retina
High resolution monitoring of stimulus-evoked retinal neural activities is important for understanding retinal neural
mechanisms, and for diagnosis of retinal disease and evaluation of treatment. Fast intrinsic optical signals (IOSs), which
have the time courses comparable to retinal electrophysiological responses, hold the promise for high resolution imaging
of retinal neural activities. However, application of fast IOS imaging has been hindered by contamination of slow, high
magnitude, optical responses associated with transient hemodynamic and metabolic changes. We recently demonstrated
the feasibility of separating fast IOSs from slow optical responses by combined dynamic differential imaging and high
frequency flicker stimulation.
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Xin-Cheng Yao, Yang-Guo Li, Lei Liu, Frank Amthor, "Dynamic differential imaging of intrinsic optical responses in the retina," Proc. SPIE 7548, Photonic Therapeutics and Diagnostics VI, 754845 (4 March 2010); https://doi.org/10.1117/12.841417