Dynamic differential imaging of intrinsic optical responses in the retina

Xin-Cheng Yao; Yang-Guo Li; Lei Liu; Frank Amthor

doi:10.1117/12.841417

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4 March 2010 Dynamic differential imaging of intrinsic optical responses in the retina

Xin-Cheng Yao, Yang-Guo Li, Lei Liu, Frank Amthor

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Proceedings Volume 7548, Photonic Therapeutics and Diagnostics VI; 754845 (2010) https://doi.org/10.1117/12.841417
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

High resolution monitoring of stimulus-evoked retinal neural activities is important for understanding retinal neural mechanisms, and for diagnosis of retinal disease and evaluation of treatment. Fast intrinsic optical signals (IOSs), which have the time courses comparable to retinal electrophysiological responses, hold the promise for high resolution imaging of retinal neural activities. However, application of fast IOS imaging has been hindered by contamination of slow, high magnitude, optical responses associated with transient hemodynamic and metabolic changes. We recently demonstrated the feasibility of separating fast IOSs from slow optical responses by combined dynamic differential imaging and high frequency flicker stimulation.

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Xin-Cheng Yao, Yang-Guo Li, Lei Liu, and Frank Amthor "Dynamic differential imaging of intrinsic optical responses in the retina", Proc. SPIE 7548, Photonic Therapeutics and Diagnostics VI, 754845 (4 March 2010); https://doi.org/10.1117/12.841417

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