3 March 2010 In vivo detection of osteoarthritis in the hand with three-dimensional photoacoustic tomography
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Proceedings Volume 7548, Photonic Therapeutics and Diagnostics VI; 75484H (2010); doi: 10.1117/12.851723
Event: SPIE BiOS, 2010, San Francisco, California, United States
Abstract
This paper presents a pilot clinical study in detecting osteoarthritis (OA) in the hand using threedimensional (3-D) photoacoustic tomography (PAT). Distal interphalangeal (DIP) finger joints from OA patients and healthy volunteers were imaged with our 3-D PAT system in a spherical scanning configuration. Absorption coefficient images of the joint tissue were obtained using our finite element based photoacoustic image reconstruction algorithm coupled with the photon diffusion equation. The recovered quantitative photoacoustic images revealed significant differences in the absorption coefficient of the joint cavity (cartilage and synovial fluid) between the OA and healthy joints. Quantitative analysis of the joints also indicated an apparent difference in the recovered joint spacing between OA and healthy subjects, which is in agreement with the clinical observations. This study suggests that 3D PAT has the potential to become a useful tool for diagnosis of osteoarthritis.
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Yao Sun, Eric Sobel, Huabei Jiang, "In vivo detection of osteoarthritis in the hand with three-dimensional photoacoustic tomography", Proc. SPIE 7548, Photonic Therapeutics and Diagnostics VI, 75484H (3 March 2010); doi: 10.1117/12.851723; https://doi.org/10.1117/12.851723
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