2 March 2010 Gaussian versus flat-top spatial beam profiles for optical stimulation of the prostate nerves
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Proceedings Volume 7548, Photonic Therapeutics and Diagnostics VI; 75484W (2010) https://doi.org/10.1117/12.852994
Event: SPIE BiOS, 2010, San Francisco, California, United States
The cavernous nerves (CN) course along the prostate surface and are responsible for erectile function. Improved identification and preservation of the CN's is critical to maintaining sexual potency after prostate cancer surgery. Noncontact optical nerve stimulation (ONS) of the CN's was recently demonstrated in a rat model, in vivo, as a potential alternative to electrical nerve stimulation (ENS) for identification of the CN's during prostate surgery. However, the therapeutic window for ONS is narrow, so optimal design of the fiber optic delivery system is critical for safe, reproducible stimulation. This study describes modeling, assembly, and testing of an ONS probe for delivering a small, collimated, flat-top laser beam for uniform CN stimulation. A direct comparison of the magnitude and response time of the intracavernosal pressure (ICP) for both Gaussian and flat-top spatial beam profiles was performed. Thulium fiber laser radiation (λ=1870 nm) was delivered through a 200-μm fiber, with distal fiber tip chemically etched to convert a Gaussian to flat-top beam profile. The laser beam was collimated to a 1-mm-diameter spot using an aspheric lens. Computer simulations of light propagation were used to optimize the probe design. The 10-Fr (3.4-mm-OD) laparoscopic probe provided a constant radiant exposure at the CN surface. The probe was tested in four rats, in vivo. ONS of the CN's was performed with a 1-mm-diameter spot, 5-ms pulse duration, and pulse rate of 20 Hz for a duration of 15-30 s. The flat-top laser beam profile consistently produced a faster and higher ICP response at a lower radiant exposure than the Gaussian beam profile due, in part, to easier alignment of the more uniform beam with nerve. The threshold for ONS was approximately 0.14 J/cm2, corresponding to a temperature increase of 6-8°C at the CN surface after a stimulation time of 15 s. With further development, ONS may be used as a diagnostic tool for identification of CN's during prostate cancer surgery.
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Serhat Tozburun, Serhat Tozburun, Gwen A. Lagoda, Gwen A. Lagoda, Arthur L. Burnett, Arthur L. Burnett, Nathaniel M. Fried, Nathaniel M. Fried, } "Gaussian versus flat-top spatial beam profiles for optical stimulation of the prostate nerves", Proc. SPIE 7548, Photonic Therapeutics and Diagnostics VI, 75484W (2 March 2010); doi: 10.1117/12.852994; https://doi.org/10.1117/12.852994

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