Bevacizumab (Avastin) conjugated microbubbles for anti-VEGF treatment of neovascular age-related macular degeneration

Leilei Zhang; Jeff Xu; Jiwei Huang; Cynthia Roberts; Ronald Xu

doi:10.1117/12.841932

2 March 2010 Bevacizumab (Avastin) conjugated microbubbles for anti-VEGF treatment of neovascular age-related macular degeneration

Leilei Zhang, Jeff Xu, Jiwei Huang, Cynthia Roberts, Ronald Xu

Author Affiliations +

Proceedings Volume 7550, Ophthalmic Technologies XX; 75501P (2010) https://doi.org/10.1117/12.841932
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

Bevacizumab (Avastin) has been used as one of the anti-VEGF therapies to manage neovascular age-related macular degeneration (AMD). The drug delivery system for bevacizumab needs to be improved in order to decrease the frequency of injection and reduce the adverse effects. In our study, bevacizumab was conjugated with poly (lactic-co-glycolic acid) (PLGA) microbubbles by activating carboxyl functional groups. The averaged size of microbubbles was estimated 1.055±0.258μm, allowing for ultrasound guided drug delivery. The binding efficiency between bevacizumab and microbubbles was evaluated in an enzyme-linked immunosorbent assay plate. The test results demonstrated the potential of using PLGA microbubbles to deliver bevacizumab with imaging guidance.

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Leilei Zhang, Jeff Xu, Jiwei Huang, Cynthia Roberts, and Ronald Xu "Bevacizumab (Avastin) conjugated microbubbles for anti-VEGF treatment of neovascular age-related macular degeneration", Proc. SPIE 7550, Ophthalmic Technologies XX, 75501P (2 March 2010); https://doi.org/10.1117/12.841932

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KEYWORDS

Therapeutics

Ultrasonography

Scanning electron microscopy

Laser scattering

Ophthalmology

Clinical trials

Luminescence

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