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2 March 2010 Patient specific integrating spheres for the improvement of dosimetry in skin PDT
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The treatment of superficial skin cancers with photodynamic therapy (PDT) relies on uniformly covering the treatment target with sufficient light fluence using an externally applied source. Incorporating an integrating sphere into the treatment procedure makes this easier to achieve. A prototype sphere was characterized using a 1% Intralipid phantom with various concentrations of India ink. Profile and depth fluence measurements were taken in the phantom with and without the sphere in place. The sphere was effective at increasing the fluence rate by up to 100% and at improving the uniformity and penumbra of the beam for all India ink concentrations. The relative increase in fluence was lower for the higher concentrations of ink. These findings were supported by Monte Carlo simulations. Additional Monte Carlo simulations investigated the relationship between the sphere parameters and the beam characteristics. Beam flatness improved with an increase in overlap of the incident beam on the sphere wall; however the fluence increase was not as large.
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Diana L. Glennie, Thomas J. Farrell, Joseph E. Hayward, Michael S. Patterson, and Greg Sawesky "Patient specific integrating spheres for the improvement of dosimetry in skin PDT", Proc. SPIE 7551, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIX, 75510W (2 March 2010);

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