In vivo light dosimetry for HPPH-mediated pleural PDT

Andreea Dimofte; Timothy C. Zhu; Jarod C. Finlay; Melissa Cullighan; Christine E. Edmonds; Joseph S. Friedberg; Keith Cengel; Stephen M. Hahn

doi:10.1117/12.851514

4 March 2010 In vivo light dosimetry for HPPH-mediated pleural PDT

Andreea Dimofte, Timothy C. Zhu, Jarod C. Finlay, Melissa Cullighan, Christine E. Edmonds, Joseph S. Friedberg, Keith Cengel, Stephen M. Hahn

Author Affiliations +

Proceedings Volume 7551, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIX; 755115 (2010) https://doi.org/10.1117/12.851514
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

This study examines the light fluence (rate) delivered to patients undergoing pleural PDT as a function of treatment time, treatment volume and surface area. The accuracy of treatment delivery is analyzed as a function of the calibration accuracies of each isotropic detector and the calibration integrating sphere. The patients studied here are enrolled in a Phase I clinical trial of HPPH-mediated PDT for the treatment of non-small cell lung cancer with pleural effusion. Patients are administered 4mg per kg body weight HPPH 24-48 hours before the surgery. Patients undergoing photodynamic therapy (PDT) are treated with light therapy with a fluence of 15-60 J/cm² at 661nm. Fluence rate (mW/cm²) and cumulative fluence (J/cm²) is monitored at 7 different sites during the entire light treatment delivery. Isotropic detectors are used for in-vivo light dosimetry. The anisotropy of each isotropic detector was found to be within 15%. The mean fluence rate delivery and treatment time are recorded. A correlation between the treatment time and the treatment volume is established. The result can be used as a clinical guideline for future pleural PDT treatment.

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Andreea Dimofte, Timothy C. Zhu, Jarod C. Finlay, Melissa Cullighan, Christine E. Edmonds, Joseph S. Friedberg, Keith Cengel, and Stephen M. Hahn "In vivo light dosimetry for HPPH-mediated pleural PDT", Proc. SPIE 7551, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIX, 755115 (4 March 2010); https://doi.org/10.1117/12.851514

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