4 March 2010 In vivo light dosimetry for HPPH-mediated pleural PDT
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Abstract
This study examines the light fluence (rate) delivered to patients undergoing pleural PDT as a function of treatment time, treatment volume and surface area. The accuracy of treatment delivery is analyzed as a function of the calibration accuracies of each isotropic detector and the calibration integrating sphere. The patients studied here are enrolled in a Phase I clinical trial of HPPH-mediated PDT for the treatment of non-small cell lung cancer with pleural effusion. Patients are administered 4mg per kg body weight HPPH 24-48 hours before the surgery. Patients undergoing photodynamic therapy (PDT) are treated with light therapy with a fluence of 15-60 J/cm2 at 661nm. Fluence rate (mW/cm2) and cumulative fluence (J/cm2) is monitored at 7 different sites during the entire light treatment delivery. Isotropic detectors are used for in-vivo light dosimetry. The anisotropy of each isotropic detector was found to be within 15%. The mean fluence rate delivery and treatment time are recorded. A correlation between the treatment time and the treatment volume is established. The result can be used as a clinical guideline for future pleural PDT treatment.
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Andreea Dimofte, Andreea Dimofte, Timothy C. Zhu, Timothy C. Zhu, Jarod C. Finlay, Jarod C. Finlay, Melissa Cullighan, Melissa Cullighan, Christine E. Edmonds, Christine E. Edmonds, Joseph S. Friedberg, Joseph S. Friedberg, Keith Cengel, Keith Cengel, Stephen M. Hahn, Stephen M. Hahn, } "In vivo light dosimetry for HPPH-mediated pleural PDT", Proc. SPIE 7551, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIX, 755115 (4 March 2010); doi: 10.1117/12.851514; https://doi.org/10.1117/12.851514
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