2 March 2010 Analytic modeling of antibody versus nanocell delivery of photosensitizer
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Abstract
Delivery of therapeutic agents to solid tumors is challenging, and the issues that govern this can be distilled down into parameters which allow computational modeling. In this paper, the basic rate equations and diffusion kernel for the time and space modeling of delivery are developed, along with an analytical solution to this equation. The model is then used to compare delivery of Avastin antibody relative to delivery encapsulated in a nanocell delivery vehicle. The key factors are the plasma clearance or excretion rates, and the binding, or not, as it transports into the tumor tissue. A reduction in the plasma clearance rate inherently increases available delivery over time, and additionally the reduction in binding from antibody to nanocell allows higher penetration into the tumor at the longer circulation times.
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Brian W. Pogue, Subhadra Srinivasan, Kimberley Samkoe, Lei Zak Zheng, Prakash Rai, Zhiming Mai, Sarika Verma, Tayyaba Hasan, "Analytic modeling of antibody versus nanocell delivery of photosensitizer", Proc. SPIE 7551, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIX, 755117 (2 March 2010); doi: 10.1117/12.853925; https://doi.org/10.1117/12.853925
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