The photobiomodulation in the bone repair after radiotherapy: experimental study in rats

M. R. S. Freire M.D.; D. Almeida; J. N. Santos; V A. Sarmento

doi:10.1117/12.842314

25 February 2010 The photobiomodulation in the bone repair after radiotherapy: experimental study in rats

M. R. S. Freire M.D., D. Almeida, J. N. Santos, V A. Sarmento

Proceedings Volume 7552, Mechanisms for Low-Light Therapy V; 75520H (2010) https://doi.org/10.1117/12.842314
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

This research evaluated the effect of the GaAlAs lasertherapy at the healing of surgical wounds produced in Wistar rats femurs few days before the beginning of the radiotherapy. For this, an orifice was artificially produced in the femur bone of the rats and they had been submitted to an external radiotherapy with a radioactive source of cobalt in the dosage of 3000 cGys. The experimental group received additionally seven sessions of 780 nm, 40 mW, 100 J/cm² or 5 J/cm² in four points around the surgical wound, at each 48 h, initiated at the day of the surgery. These animals had been sacrificed in three and five weeks. The results show that the number of osteocites (p< 0,0001) and Harvers channels (p< 0,0001) were significantly larger in the groups that had been radiated with laser during the experiment.

Citation Download Citation

M. R. S. Freire M.D., D. Almeida, J. N. Santos, and V A. Sarmento "The photobiomodulation in the bone repair after radiotherapy: experimental study in rats", Proc. SPIE 7552, Mechanisms for Low-Light Therapy V, 75520H (25 February 2010); https://doi.org/10.1117/12.842314

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