25 February 2010 Enhanced PNA detection sensitivity based on polymer-cladded porous silicon waveguide
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Abstract
In this work, we theoretically and experimentally demonstrate a highly sensitive polymer-cladded porous silicon (PSi) membrane waveguide based on a ~1.55 μm thick porous silicon membrane coated on one side with a low loss polymer. The sensor operates in the Kretschmann configuration, which is amenable to microfluidics integration, with a high index cubic zirconium prism. The sensitivity of the sensor is investigated through PNA hybridization in the PSi membrane. We demonstrate that higher angle resonances and a proper ratio of PNA length to PSi pore diameter lead to significantly improved detection sensitivity. A detection sensitivity below 0.1°/μM is reported for 16mer target PNA. Calculations and complimentary experiments show that careful tuning of the polymer cladding thickness can further improve the detection performance.
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Yang Jiao, Yang Jiao, Sharon M. Weiss, Sharon M. Weiss, } "Enhanced PNA detection sensitivity based on polymer-cladded porous silicon waveguide", Proc. SPIE 7553, Frontiers in Pathogen Detection: From Nanosensors to Systems, 75530O (25 February 2010); doi: 10.1117/12.842258; https://doi.org/10.1117/12.842258
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