19 February 2010 Adaptive optics spectral domain optical coherence tomography with one-micrometer light source
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Adaptive optics spectral domain optical coherence tomography (AO SD-OCT) has provided three-dimensional high isotropic resolution retinal images in vivo. In order to enhance the image quality of deep region of the eye, the alternative wavelength of 1-μm has been used for ophthalmic OCT. This study aims to develop AO SD-OCT with one-micrometer probe and demonstrated high penetration and high resolution retinal imaging. A broadband 1-μm SLD light source (Suplerlum) have the center wavelength of 1.03 μm and the spectral bandwidth of 106 nm. Axial scans were obtained by an InGaAs line scan camera with the speed of 47,000 Hz. The aberrations of the system and the eye were measured by Shack-Hartmann wavefront sensor (HASO32, Imagine Eyes, France) and corrected by a single deformable mirror (Mirao52, Imagine Eyes). The AO closed loop was working with the iteration frequency of 7 Hz. The residual root mean square (RMS) wavefront error was typically reduced to 0.1 μm. Seven eyes of 7 normal subjects were examined. The signal gain was found for all subjects with AO. The waving interface of nerve fiber layer and ganglion cell layer, the interface between ganglion cell layer and inner plexiform layer and choroid-sclera interface were observed. AO SD-OCT with one-micrometer probe may be useful not only for the investigation of photoreceptors but also nerve fiber abnormalities.
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Kazuhiro Kurokawa, Kazuhiro Kurokawa, Kazuhiro Sasaki, Kazuhiro Sasaki, Shuichi Makita, Shuichi Makita, Yoshiaki Yasuno, Yoshiaki Yasuno, } "Adaptive optics spectral domain optical coherence tomography with one-micrometer light source", Proc. SPIE 7554, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIV, 75540E (19 February 2010); doi: 10.1117/12.841666; https://doi.org/10.1117/12.841666

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