19 February 2010 Optimizing penetration depth, contrast, and resolution in 3D dermatologic OCT
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Abstract
High speed, three-dimensional optical coherence tomography (3D OCT) at 800nm, 1060nm and 1300nm with approximately 4μm, 7μm and 6μm axial and less than 15μm transverse resolution is demonstrated to investigate the optimum wavelength region for in vivo human skin imaging in terms of contrast, dynamic range and penetration depth. 3D OCT at 1300nm provides deeper penetration, while images obtained at 800nm were better in terms of contrast and speckle noise. 1060nm region was a compromise between 800nm and 1300nm in terms of penetration depth and image contrast. Optimizing sensitivity, penetration and contrast enabled unprecedented visualization of micro-structural morphology underneath the glabrous skin, hairy skin and in scar tissue. Higher contrast obtained at 800 nm appears to be critical in the in vitro tumor study. A multimodal approach combining OCT and PA helped to obtain morphological as well as vascular information from deeper regions of skin.
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Alex Aneesh, Alex Aneesh, Boris Považay, Boris Považay, Bernd Hofer, Bernd Hofer, Edward Z. Zhang, Edward Z. Zhang, Catherine Kendall, Catherine Kendall, Jan Laufer, Jan Laufer, Sergei Popov, Sergei Popov, Carl Glittenberg, Carl Glittenberg, Susanne Binder, Susanne Binder, Nicholas Stone, Nicholas Stone, Paul C Beard, Paul C Beard, Wolfgang Drexler, Wolfgang Drexler, "Optimizing penetration depth, contrast, and resolution in 3D dermatologic OCT", Proc. SPIE 7554, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIV, 75540V (19 February 2010); doi: 10.1117/12.843243; https://doi.org/10.1117/12.843243
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