Optical Doppler tomography and spectral Doppler imaging of localized ischemic stroke in a mouse model

Lingfeng Yu; Elaine Nguyen; Gangjun Liu; Bin Rao; Bernard Choi; Zhongping Chen

doi:10.1117/12.843016

19 February 2010 Optical Doppler tomography and spectral Doppler imaging of localized ischemic stroke in a mouse model

Lingfeng Yu, Elaine Nguyen, Gangjun Liu, Bin Rao, Bernard Choi, Zhongping Chen

Proceedings Volume 7554, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIV; 75542E (2010) https://doi.org/10.1117/12.843016
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

We present a combined optical Doppler tomography/spectral Doppler imaging modality to quantitatively evaluate the dynamic blood circulation and the artery blockage before and after a localized ischemic stroke in a mouse model. Optical Doppler Tomography (ODT) combines the Doppler principle with optical coherence tomography for noninvasive localization and measurement of particle flow velocity in highly scattering media with micrometer scale spatial resolution. Spectral Doppler imaging (SDI) provides complementary temporal flow information to the spatially distributed flow information of Doppler imaging. Fast, repeated, ODT scans across an entire vessel were performed to record flow dynamic information with high temporal resolution of cardiac cycles. Spectral Doppler analysis of continuous Doppler images demonstrates how the velocity components and longitudinally projected flow-volume-rate change over time for scatters within the imaging volume using spectral Doppler waveforms. Furthermore, vascular conditions can be quantified with various Doppler-angle-independent flow indices. Non-invasive in-vivo mice experiments were performed to evaluate microvascular blood circulation of a localized ischemic stroke mouse model.

Citation Download Citation

Lingfeng Yu, Elaine Nguyen, Gangjun Liu, Bin Rao, Bernard Choi, and Zhongping Chen "Optical Doppler tomography and spectral Doppler imaging of localized ischemic stroke in a mouse model", Proc. SPIE 7554, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIV, 75542E (19 February 2010); https://doi.org/10.1117/12.843016

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KEYWORDS

Doppler tomography

Ischemic stroke

Optical coherence tomography

Blood circulation

Doppler effect

Mouse models

Arteries

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