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19 February 2010Multi-beam resolution video-rate swept-source optical coherence tomography (OCT) provides endogenous contrast for in vivo blood flow
independent of flow direction
Optical coherence tomography (OCT) allows non-invasive imaging of sub-surface structures in vivo, ideally without a
need for target preparation. In conventional OCT, the contrast for blood vessels depends on a variety of factors and can
be challenging. Speckle variance has been recognized as a method to enhance contrast for blood flow without the
application of contrast agents in OCT images.
Here, we demonstrate the possibility of extracting blood flow information from a volumetric OCT datasets that was
obtained routinely from a human participant. We used a commercially available OCT system with a clinical CE-mark.
The light source has a central wavelength of 1310 nm. Using Multi-Beam technology, the system achieves an isometric
resolution of better than 7.5 μm in tissue over the entire imaging depth of around 1 mm. At 1 mm image width, 21
frames (B-scans) per second can be imaged.
We used the speckle variance in order to enhance the contrast for blood vessels in vivo. This method allowed us
determining the presence and depth of blood flow within the 1 mm penetration depth, without dependence on direction
or orientation of the blood flow with respect to the scanning beam.
F. Bazant-Hegemark,D. Woods,S. Hattersley, andJ. Holmes
"Multi-beam resolution video-rate swept-source optical coherence tomography (OCT) provides endogenous contrast for in vivo blood flow
independent of flow direction", Proc. SPIE 7554, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIV, 75542Z (19 February 2010); https://doi.org/10.1117/12.841906
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F. Bazant-Hegemark, D. Woods, S. Hattersley, J. Holmes, "Multi-beam resolution video-rate swept-source optical coherence tomography (OCT) provides endogenous contrast for in vivo blood flow independent of flow direction," Proc. SPIE 7554, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIV, 75542Z (19 February 2010); https://doi.org/10.1117/12.841906