20 February 2010 Clinically compatible instrumentation for accurate detection of fluorescence intensity and lifetime in turbid media
Author Affiliations +
Proceedings Volume 7555, Advanced Biomedical and Clinical Diagnostic Systems VIII; 755503 (2010); doi: 10.1117/12.845789
Event: SPIE BiOS, 2010, San Francisco, California, United States
Abstract
We report data collected with a specialized transient digitizer, high repetition rate microchip laser sources, and fiber optic light delivery and collection for rapid remote sensing in tissue-simulating phantoms. The instrumentation is highly suitable for eventual translation to a clinical setting owing to the speed of data acquisition and small footprint. Ranges for data acquisition time and instrument sensitivity were determined by measuring wavelength time matrices (WTMs) from tissue-simulating phantoms. Accuracy of WTM data was validated by comparison with Monte-Carlo simulations of fluorescent light propagation in turbid media.
© (2010) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Ching-Wei Chang, William Lloyd, Robert Wilson, Gregory D. Gillispie, Mary-Ann Mycek, "Clinically compatible instrumentation for accurate detection of fluorescence intensity and lifetime in turbid media", Proc. SPIE 7555, Advanced Biomedical and Clinical Diagnostic Systems VIII, 755503 (20 February 2010); doi: 10.1117/12.845789; http://dx.doi.org/10.1117/12.845789
PROCEEDINGS
6 PAGES


SHARE
KEYWORDS
Luminescence

Collagen

Tissues

Monte Carlo methods

Scattering

Fluorescence spectroscopy

Data acquisition

Back to Top