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22 February 2010 Monitoring of tissue perfusion during esophagectomies with optical fiber probe spectroscopy
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Abstract
The specific optical spectra of tissues contain information about the biochemical composition. We present a simple optical fiber probe spectrometer design for noninvasive measurement of oxygen saturation in the microvasculature of stomach tissue. In a human Esophagectomy model with 23 patients, we measured the spectrum following surgical ligation of two of the three arterial paths to the stomach tissue that will become the anastamosis. Combining a diffusion model for semi-infinite slab remittance with absorption spectroscopy, we are able to specify the ratio of oxy-hemoglobin to deoxy-hemoglobin present in the tissue. We show a resting state of 0.47 (oxy-hemaglobin/total-hemaglobin) saturation decrease of 29% (p < 0.01) when arterial supply is reduced by artery ligation.
© (2010) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Dan Gareau, John Hunter M.D., and Steven Jacques "Monitoring of tissue perfusion during esophagectomies with optical fiber probe spectroscopy", Proc. SPIE 7555, Advanced Biomedical and Clinical Diagnostic Systems VIII, 75551C (22 February 2010); https://doi.org/10.1117/12.843705
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