22 February 2010 Integrated micro-total analysis system (μTAS) for biophotonic enzymatic detections
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Abstract
Lab-on-a-chip or Micro total analysis systems (μTAS) technologies offer a lot of potential applications for biosensing and biomedical detections. This paper presents the design, fabrication and characterization of a fully integrated siliconpolymer based biophotonic Micro-Total Analysis System for the real-time detection of enzymes and antigens. This device uses optical detection methods i.e, optical absorption, Laser induced fluorescence and evanescence measurement technique to detect the presence, concentration and the activity of biomolecules. The main components of the proposed system are microfluidic unit and micromechanical fluid actuation system, integrated with the optical detection systems. An Echelle grating based Spectrometer-on-Chip on Silica-on-Silicon (SOS) is integrated with the opto-microfluidic assembly for fluorescence detection. On-Chip fabrication and integration of valveless micropump has been carried out in order to facilitate the transportation of fluid within the system. The important advantages of the proposed μTAS are functional independence of each module of the system, simultaneous multi-analyte detection, rapid, precise and discriminating results, low background/high signal-to-noise ratio, lack of moving parts, robust, portability, and feasibility of bulk fabrication.
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Arvind Chandrasekaran, Arvind Chandrasekaran, Muthukumaran Packirisamy, Muthukumaran Packirisamy, } "Integrated micro-total analysis system (μTAS) for biophotonic enzymatic detections", Proc. SPIE 7555, Advanced Biomedical and Clinical Diagnostic Systems VIII, 75551D (22 February 2010); doi: 10.1117/12.843718; https://doi.org/10.1117/12.843718
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