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22 February 2010 Signal-to-noise analysis for 3D luminescence imaging of hypoxia in deep tissues
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Abstract
We provide a detailed signal-to-noise analysis for 3D imaging of luminescence from a biomarker to detect hypoxic tumors in deep tissue. Preliminary studies on phantom tissues with inclusions and having homogeneous scattering and absorption coefficient of μs' ~ 15-20 cm-1 and μa ~ 2 cm-1 respectively, are reported as a function of oxygen tension, luminophore concentration, and tissue depth. The technique's sensitivity in terms of determination of spatial resolution is discussed.
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Rajan Gurjar, Madhavi Seetamraju, and David Wolf "Signal-to-noise analysis for 3D luminescence imaging of hypoxia in deep tissues", Proc. SPIE 7555, Advanced Biomedical and Clinical Diagnostic Systems VIII, 75551J (22 February 2010); doi: 10.1117/12.840736; https://doi.org/10.1117/12.840736
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