23 February 2010 Assessment of pressure, angle, and temporal effects on polarization-gated spectroscopic probe measurements
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Abstract
Noninvasive and real-time analysis of tissue properties, in particular, the quantitative assessment of blood content and light scattering properties of mucosa is useful in a wide variety of applications. However, the nature of interactions between contact fiber-optic probes and the tissue surface presents a challenging problem with respect to the variability of in vivo measurements, for example affects due to variations in the pressure and angle of the probe tip on the tissue surface. Previously, pressure and angle effects have been investigated for other modalities (i.e. diffuse reflectance and Raman spectroscopy). We present an evaluation of this variability, as well as the length of time in contact with tissue for polarization-gated spectroscopy. The evaluation is based on the quantification of mucosal blood content at superficial depths (within 100 to 200 microns of tissue surface) for in vivo measurements of oral mucosa. Measurements are presented for different pressures, angles and time scales and the variability due to these factors is assessed.
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Sarah Ruderman, Sarah Ruderman, Valentina Stoyneva, Valentina Stoyneva, Andrew J. Gomes, Andrew J. Gomes, Jeremy D. Rogers, Jeremy D. Rogers, Vadim Backman, Vadim Backman, } "Assessment of pressure, angle, and temporal effects on polarization-gated spectroscopic probe measurements", Proc. SPIE 7556, Design and Quality for Biomedical Technologies III, 75560K (23 February 2010); doi: 10.1117/12.842857; https://doi.org/10.1117/12.842857
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