24 February 2010 Development of a bi-modality XCT: fDOT instrument
Author Affiliations +
Proceedings Volume 7557, Multimodal Biomedical Imaging V; 755709 (2010); doi: 10.1117/12.840374
Event: SPIE BiOS, 2010, San Francisco, California, United States
We present first results of a fluorescence optical diffusion tomography experiment coupled to a X-ray computed tomography reconstruction. An instrument, dedicated to the co-registration of optical and X-ray measurements, has been developed: specific acquisition protocol and reconstruction software have been developed for carrying out fluorescence diffuse optical tomography in a cylindrical geometry consistent with X-ray tomography. Actual animal geometry provided by the X-ray tomography is used to give animal boundaries to the diffuse optical tomography reconstruction algorithm. Experiments have been conducted on sacrificed mice and fluorescence reconstructions have been evaluated and are geometrically consistent with X-ray ones.
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Anne Koenig, Anne Planat-Chrétien, Jean-Guillaume Coutard, Lionel Hervé, Ludovic Lecordier, Marco Brambilla, Jean-Marc Dinten, "Development of a bi-modality XCT: fDOT instrument", Proc. SPIE 7557, Multimodal Biomedical Imaging V, 755709 (24 February 2010); doi: 10.1117/12.840374; https://doi.org/10.1117/12.840374



X-ray optics

Reconstruction algorithms

Diffuse optical tomography

X-ray fluorescence spectroscopy


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