11 March 2010 A hybrid fluorescence tomography and x-ray CT system for quantitative molecular imaging
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Proceedings Volume 7557, Multimodal Biomedical Imaging V; 75570A (2010) https://doi.org/10.1117/12.842773
Event: SPIE BiOS, 2010, San Francisco, California, United States
A gantry-based hybrid fluorescence and x-ray computed tomography (FT/CT) system is developed for quantitative molecular imaging. The performance of the dual modality FT/CT system is evaluated using an irregular shaped phantom with an inclusion containing Indocyanine-Green (ICG). The anatomical data from CT provides structural a priori information for the FT inverse problem. Although a 4.2 mm diameter inclusion can be resolved in the reconstructed concentration image without any a priori information, ICG concentration in the inclusion is recovered with 75% error. On the other hand, the error in the recovered ICG concentration reduces to 15% when a priori information from CT is utilized. The results demonstrate that accurate fluorophore concentration can only be obtained when x-ray CT structural a priori information is available.
© (2010) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Yuting Lin, Yuting Lin, William C. Barber, William C. Barber, Jan S. Iwanczk, Jan S. Iwanczk, Werner W. Roeck, Werner W. Roeck, Orhan Nalcioglu, Orhan Nalcioglu, Gultekin Gulsen, Gultekin Gulsen, } "A hybrid fluorescence tomography and x-ray CT system for quantitative molecular imaging", Proc. SPIE 7557, Multimodal Biomedical Imaging V, 75570A (11 March 2010); doi: 10.1117/12.842773; https://doi.org/10.1117/12.842773

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