A multimodal contrast agent for simultaneous magnetic resonance and optical imaging of small animal

M. B. Unlu; Y. Lin; B. Grimmond; A. Sood; E. Uzgiris; O. Nalcioglu; G. Gulsen

doi:10.1117/12.843240

23 February 2010 A multimodal contrast agent for simultaneous magnetic resonance and optical imaging of small animal

M. B. Unlu, Y. Lin, B. Grimmond, A. Sood, E. Uzgiris, O. Nalcioglu, G. Gulsen

Proceedings Volume 7557, Multimodal Biomedical Imaging V; 75570C (2010) https://doi.org/10.1117/12.843240
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

Our goal is to assess the feasibility of a bi-functional contrast agent that is intravenously injected to an R3230 induced small animal breast tumor model. The MR/optical contrast agent was produced by GE Global Research, NY, and it was available in one size, Dp20. We used a combined frequency domain diffuse optical tomography (DOT) and a 4T magnetic resonance (MR) scanner to simultaneously measure the kinetics of the contrast agent in vivo. Both systems detected the signal change in the tumor and the non-tumor region. MR measurements served as a gold standard to validate the optical kinetics. We present both MR and DOT dynamic curves as well as the reconstructed optical absorption map.

Citation Download Citation

M. B. Unlu, Y. Lin, B. Grimmond, A. Sood, E. Uzgiris, O. Nalcioglu, and G. Gulsen "A multimodal contrast agent for simultaneous magnetic resonance and optical imaging of small animal", Proc. SPIE 7557, Multimodal Biomedical Imaging V, 75570C (23 February 2010); https://doi.org/10.1117/12.843240

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KEYWORDS

Magnetic resonance imaging

Tumors

Absorption

Image enhancement

In vivo imaging

Magnetism

Optical imaging

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