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23 February 2010 Integrated intravascular optical coherence tomography (OCT) - ultrasound (US) imaging system
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Proceedings Volume 7557, Multimodal Biomedical Imaging V; 75570D (2010)
Event: SPIE BiOS, 2010, San Francisco, California, United States
Optical coherence tomography (OCT) and intravascular ultrasound (IVUS) are considered two complementary imaging techniques in the detection and diagnosis of atherosclerosis. OCT permits visualization of micron-scale features of atherosclerosis plaque, and IVUS offers full imaging depth of vessel wall. Under the guidance of IVUS, minimal amount of flushing agent will be needed to obtain OCT imaging of the interested area. We report on a dual-modality optical coherence tomography (OCT) - ultrasound (US) system for intravascular imaging. To the best of our knowledge, we have developed the first integrated OCT-US probe that combines OCT optical components with an ultrasound transducer. The OCT optical components mainly consist of a single mode fiber, a gradient index (GRIN) lens for light beam focusing, and a right-angled prism for reflecting light into biological tissue. A 40MHz PZT-5H side-viewing ultrasound transducer was fabricated to obtain the ultrasound image. These components were integrated into a single probe, enabling both OCT and ultrasound imaging at the same time. In vitro OCT and ultrasound images of a rabbit aorta were obtained using this dual-modality imaging system. This study demonstrates the feasibility of an OCT-US system for intravascular imaging which is expected to have a prominent impact on early detection and characterization of atherosclerosis.
© (2010) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Jiechen Yin, Hao-Chung Yang, Xiang Li, Qifa Zhou, Changhong Hu, Jun Zhang, K. Kirk Shung, and Zhongping Chen "Integrated intravascular optical coherence tomography (OCT) - ultrasound (US) imaging system", Proc. SPIE 7557, Multimodal Biomedical Imaging V, 75570D (23 February 2010);

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