23 February 2010 Integrated intravascular optical coherence tomography (OCT) - ultrasound (US) imaging system
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Proceedings Volume 7557, Multimodal Biomedical Imaging V; 75570D (2010) https://doi.org/10.1117/12.841375
Event: SPIE BiOS, 2010, San Francisco, California, United States
Abstract
Optical coherence tomography (OCT) and intravascular ultrasound (IVUS) are considered two complementary imaging techniques in the detection and diagnosis of atherosclerosis. OCT permits visualization of micron-scale features of atherosclerosis plaque, and IVUS offers full imaging depth of vessel wall. Under the guidance of IVUS, minimal amount of flushing agent will be needed to obtain OCT imaging of the interested area. We report on a dual-modality optical coherence tomography (OCT) - ultrasound (US) system for intravascular imaging. To the best of our knowledge, we have developed the first integrated OCT-US probe that combines OCT optical components with an ultrasound transducer. The OCT optical components mainly consist of a single mode fiber, a gradient index (GRIN) lens for light beam focusing, and a right-angled prism for reflecting light into biological tissue. A 40MHz PZT-5H side-viewing ultrasound transducer was fabricated to obtain the ultrasound image. These components were integrated into a single probe, enabling both OCT and ultrasound imaging at the same time. In vitro OCT and ultrasound images of a rabbit aorta were obtained using this dual-modality imaging system. This study demonstrates the feasibility of an OCT-US system for intravascular imaging which is expected to have a prominent impact on early detection and characterization of atherosclerosis.
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Jiechen Yin, Jiechen Yin, Hao-Chung Yang, Hao-Chung Yang, Xiang Li, Xiang Li, Qifa Zhou, Qifa Zhou, Changhong Hu, Changhong Hu, Jun Zhang, Jun Zhang, K. Kirk Shung, K. Kirk Shung, Zhongping Chen, Zhongping Chen, } "Integrated intravascular optical coherence tomography (OCT) - ultrasound (US) imaging system", Proc. SPIE 7557, Multimodal Biomedical Imaging V, 75570D (23 February 2010); doi: 10.1117/12.841375; https://doi.org/10.1117/12.841375
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