X-Ray and near-infrared imaging: similarities, differences and combinations

Brian W. Pogue

doi:10.1117/12.849679

23 February 2010 X-Ray and near-infrared imaging: similarities, differences and combinations

Brian W. Pogue

Proceedings Volume 7557, Multimodal Biomedical Imaging V; 75570I (2010) https://doi.org/10.1117/12.849679
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

The integration of x-ray imaging with optical imaging is becoming routine at the pre-clinical level, as both projection and tomography systems are now commercially integrated as packaged systems. Yet, the differences between their capabilities are wide, and there is still perhaps a lack of appreciation about how difference pre-clinical x-ray systems are from clinical x-ray systems. In this survey, the key advantages of each approach, x-ray and optical, are described, and the potential synergies and deficiencies are discussed. In simple terms, the major benefit of optical imaging is in the spectroscopic capabilities, which allow the potential for imaging fluorescent agents in vivo, and the future potential for imaging multiple species at a time with spectral discrimination or spectral fitting of the data. In comparison, multienergy x-ray systems are being realized in clinical use, or automated discrimination of soft versus hard tissues, and the combination of optical imaging with this type of dual-energy x-ray imaging will significantly enhance the capabilities of the hybrid systems. Unfortunately, the power of dual energy imaging is not as possible at the pre-clinical stage, because of the limitations of contrast-resolution and x-ray dose. This is discussed and future human systems outlined.

Citation Download Citation

Brian W. Pogue "X-Ray and near-infrared imaging: similarities, differences and combinations", Proc. SPIE 7557, Multimodal Biomedical Imaging V, 75570I (23 February 2010); https://doi.org/10.1117/12.849679

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