A multichannel fiber optic photoluminescence system for multiplex biosensor arrays

Zhangjing Yi; Zhong Zhong; Kenneth F. Reardon; Weina Wang; Manasi Katragadda; Kevin L. Lear

doi:10.1117/12.842900

24 February 2010 A multichannel fiber optic photoluminescence system for multiplex biosensor arrays

Zhangjing Yi, Zhong Zhong, Kenneth F. Reardon, Weina Wang, Manasi Katragadda, Kevin L. Lear

Proceedings Volume 7559, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications X; 75590T (2010) https://doi.org/10.1117/12.842900
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

A multi-channel fiber optic photoluminescence system was developed for real time, in situ and continuous quantitative monitoring of chemical parameters in analytes, with the advantages of ease of use and low cost in manufacturing. The system sequentially excites 8 optodes and measures the resulting photoluminescence with a single photomultiplier. The oxygen sensitive phosphorescent dye or pH sensitive fluorescent dye in the optodes transduces the activity of an enzyme genetically engineered to detect a specific chemical species such as a chlorinated ethene. System operation is described and the relative signal is compared to measurements made with single channel system based on a commercial spectrometer.

Citation Download Citation

Zhangjing Yi, Zhong Zhong, Kenneth F. Reardon, Weina Wang, Manasi Katragadda, and Kevin L. Lear "A multichannel fiber optic photoluminescence system for multiplex biosensor arrays", Proc. SPIE 7559, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications X, 75590T (24 February 2010); https://doi.org/10.1117/12.842900

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