Polymer-functionalized microspheres for immunosensing applications

S. Soria; F. Baldini; S. Berneschi; M. Brenci; F. Cosi; A. Giannetti; G. Nunzi conti; S. Pelli; G. C. Righini; B. Tiribilli

doi:10.1117/12.841878

24 February 2010 Polymer-functionalised microspheres for immunosensing applications

S. Soria, F. Baldini, S. Berneschi, M. Brenci, F. Cosi, A. Giannetti, G. Nunzi conti, S. Pelli, G. C. Righini, B. Tiribilli

Author Affiliations +

Proceedings Volume 7559, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications X; 75590W (2010) https://doi.org/10.1117/12.841878
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

Homogeneous polymeric thin layers have been used as functionalising agents on silica microresonators in view of immunosensing applications. We have characterised the microspheres functionalised with poly-L-lactic acid and Eudragit® L100, as an alternative to the commonly used silanes. It is shown that after polymeric functionalization the quality factor of the silica microspheres remains around 10⁷, and that the Q factor is still about 3x10⁵ after chemical activation and covalent binding of immunogammaglobulin. This functionalising process of the microresonator constitutes a promising step towards the achievement of a highly sensitive immunosensor.

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S. Soria, F. Baldini, S. Berneschi, M. Brenci, F. Cosi, A. Giannetti, G. Nunzi conti, S. Pelli, G. C. Righini, and B. Tiribilli "Polymer-functionalised microspheres for immunosensing applications", Proc. SPIE 7559, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications X, 75590W (24 February 2010); https://doi.org/10.1117/12.841878

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