23 February 2010 In vivo Raman spectroscopy integrated with multimodal endoscopic imaging for early diagnosis of gastric dysplasia
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Abstract
A near-infrared Raman spectroscopy system integrated with multimodal endoscopic imaging has been developed for the early noninvasive in vivo diagnosis and detection of gastric malignancies. High-quality in vivo Raman spectra in the range 800-1800 cm-1 can be acquired from gastric normal and premalignant (dysplastic) mucosal tissue within 1 second under the guidance of white-light and narrow-band gastroscopic imaging during clinical gastroscopy. Prominent differences in Raman spectral shapes and intensities are observed between normal and dysplastic gastric mucosal tissue, particularly in the spectral ranges 800-900, 1250-1450 and 1600-1800 cm-1, which primarily contain signals related to proteins, nucleic acids and lipids. The empirical intensity ratio algorithm I875/I1450 classifies in vivo Raman spectra of dysplasia with a sensitivity of 100% and specificity of 100%. Our initial investigations show that in vivo Raman spectroscopy in conjunction with multimodal endoscopic imaging modalities holds a great promise for improving the early diagnosis of gastric malignancies.
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Mads Sylvest Bergholt, Mads Sylvest Bergholt, Wei Zheng, Wei Zheng, Kan Lin, Kan Lin, Khek Yu Ho, Khek Yu Ho, Ming Teh, Ming Teh, Khay Guan Yeoh, Khay Guan Yeoh, Zhiwei Huang, Zhiwei Huang, } "In vivo Raman spectroscopy integrated with multimodal endoscopic imaging for early diagnosis of gastric dysplasia", Proc. SPIE 7560, Biomedical Vibrational Spectroscopy IV: Advances in Research and Industry, 756003 (23 February 2010); doi: 10.1117/12.841822; https://doi.org/10.1117/12.841822
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