25 February 2010 Selective cancer therapy via IR-laser-excited gold nanorods
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Abstract
This study evaluated the effectiveness of near-infrared laser-excited gold nanorods as the active target to selectively kill the cancer cells. The key parameters of laser and sample to be measured include the absorption coefficient, the laser fluence and irradiation time, and the temperature profiles. The optimal laser operation for the surface and volume heating was achieved by a novel pulsed-train technique using an auto-controlled laser on-off time to meet the desired temperatures. The measured temperature is an increasing function of laser fluence and irradiation time. For a fixed laser influence, GNRs solution with smaller extinction coefficients (A) provides higher volume temperature, but slower surface raising speed. This novel measured features are predicted by our theory based on a heat diffusion equation, which was solved numerically, for volume heating.
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Jui-Teng Lin, Yu-Ling Hong, Chun-Lin Chang, "Selective cancer therapy via IR-laser-excited gold nanorods", Proc. SPIE 7562, Optical Interactions with Tissues and Cells XXI, 75620R (25 February 2010); doi: 10.1117/12.841348; https://doi.org/10.1117/12.841348
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