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23 February 2010 Quantification of microbubbles in blood with phase-sensitive SSOCT
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We have developed a phase stabilized swept source optical coherence tomography (PhS-SSOCT), that shows an axial resolution of 10 μm, phase sensitivity of 0.04 radians, imaging depth of up to 6 mm in air and a scanning speed of 20 kHz for a single A-line. In this paper, the PhS-SSOCT is applied to quantify gas microbubbles in blood in vitro. The results indicate that the system is able to detect bubbles of diameters greater than 10 μm using the structural image and the microbubbles of diameter less than 10 μm could be detected using the temporal phase response. Images of the bubbles of diameters 600 μm, 405 μm and 6 μm along with their phase responses are presented. Results indicate that the PhS-SSOCT could be potentially used for rapid assessment of blood microbubbles in vivo that cause diseases associated with decompression sickness, venous and arterial gas emboli and barotraumas. Eventually, PhS-SSOCT can be utilized as an early diagnostic tool for clinical purposes.
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Ravi Kiran Manapuram, Venugopal Reddy Manne, Narendran Sudheendran, Esteban F. Carbajal, and Kirill V. Larin "Quantification of microbubbles in blood with phase-sensitive SSOCT", Proc. SPIE 7563, Dynamics and Fluctuations in Biomedical Photonics VII, 75630B (23 February 2010);

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