23 February 2010 Analysis and modification of estimate error in optical properties measurement with the double-integrating-spheres system
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Abstract
The estimate of tissue optical properties is an important challenge in biomedical science. In the research of precancerous diagnosis and glucose concentration detection, the accuracy of chromospheres concentrations measurement depends on the measurement of absorption coefficient. So determining the absorption coefficient accurately is crucial both in vivo and in vitro. The Double-Integrating-Spheres (DIS) system is widely used in measuring optical properties of tissue. As there are light losses, sphere alters and cross talk in the measurement with DIS system, the estimating error of the optical properties increases, especially for absorption coefficient. Based on the DIS setup, the Monte Carlo simulation and principle of the integrating sphere are applied to investigate the effects of light loss and cross talk with various parameters of sample. According to the investigation, a fast correcting method is introduced to modify the measuring results. After a calibration dataset was employed, the algorithm based on artificial neutral network is applied to modify the measurement with DIS system. The modified results indicate that the reconstruction accuracy of absorption coefficient is fully improved compared with the uncorrected ones.
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Chenxi Li, Qiuyin Wang, Zhenzhi Shi, Yunhan Luo, Huijuan Zhao, Kexin Xu, "Analysis and modification of estimate error in optical properties measurement with the double-integrating-spheres system", Proc. SPIE 7563, Dynamics and Fluctuations in Biomedical Photonics VII, 75630O (23 February 2010); doi: 10.1117/12.841268; https://doi.org/10.1117/12.841268
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