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25 February 2010 Qualitative optical evaluation of malignancies related to cutaneous phototype
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Spectral techniques used for early diagnosis of skin cancer give to the investigators diagnostically important features usually in the process of comparison of signals received from normal and abnormal skin sites. In this study are presented some initial results of fluorescence for early detection of cutaneous tumors. However, due to great variety of optical properties and choromophores' distribution spectra of "normal" skin could have observable differences between themselves. Diagnostically significant features, such as intensity, appearance of specific minima or maxima in the spectra received, depend from anatomic place, ages, cutaneous phototype, when are measured in vivo. Therefore, development of objective differentiation algorithms for early diagnosis of skin pathologies will strongly depend from our understanding - what is the influence of major fluorophores and absorbers in the spectra observed in defined as "healthy" skin sites, and how these spectral peculiarities could influent the spectra received from lesion sites, distorting our diagnosis. In such way, we could obtain complete picture of normal skin fluorescence properties, which will be the background for comparison with any cutaneous pathology, appearing on the patient skin surface, useful for early diagnostics and alert for pre-cancerous conditions and large areas observations.
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E. Borisova, L. Avramov, P. Pavlova, E. Pavlova, and P. Troyanova "Qualitative optical evaluation of malignancies related to cutaneous phototype", Proc. SPIE 7563, Dynamics and Fluctuations in Biomedical Photonics VII, 75630X (25 February 2010);

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