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23 February 2010 Optical-resolution photoacoustic microscopy of angiogenesis in a transgenic mouse model
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A major obstacle in studying angiogenesis is the inability to noninvasively image neovascular development in an individual animal. We applied optical-resolution photoacoustic microscopy (OR-PAM) to determine the kinetics of hypoxia-inducible factor-1 (HIF-1)-mediated angiogenesis in a transgenic mouse model. During continuous 30-day activation of HIF-1α, we used OR-PAM to monitor alterations in microvasculature in transgenic mice compared to nontransgenic mice. OR-PAM has demonstrated the potential to precisely monitor antiangiogenic therapy of human cancers, allowing for rapid determinations of therapeutic efficacy or resistance.
© (2010) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Song Hu, Sunday Oladipupo, Junjie Yao, Andrea C. Santeford, Konstantin Maslov, Joanna Kovalski, Jeffrey M. Arbeit, and Lihong V. Wang "Optical-resolution photoacoustic microscopy of angiogenesis in a transgenic mouse model", Proc. SPIE 7564, Photons Plus Ultrasound: Imaging and Sensing 2010, 756406 (23 February 2010);

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