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23 February 2010 Optical-resolution photoacoustic microscopy of angiogenesis in a transgenic mouse model
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Abstract
A major obstacle in studying angiogenesis is the inability to noninvasively image neovascular development in an individual animal. We applied optical-resolution photoacoustic microscopy (OR-PAM) to determine the kinetics of hypoxia-inducible factor-1 (HIF-1)-mediated angiogenesis in a transgenic mouse model. During continuous 30-day activation of HIF-1α, we used OR-PAM to monitor alterations in microvasculature in transgenic mice compared to nontransgenic mice. OR-PAM has demonstrated the potential to precisely monitor antiangiogenic therapy of human cancers, allowing for rapid determinations of therapeutic efficacy or resistance.
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Song Hu, Sunday Oladipupo, Junjie Yao, Andrea C. Santeford, Konstantin Maslov, Joanna Kovalski, Jeffrey M. Arbeit, and Lihong V. Wang "Optical-resolution photoacoustic microscopy of angiogenesis in a transgenic mouse model", Proc. SPIE 7564, Photons Plus Ultrasound: Imaging and Sensing 2010, 756406 (23 February 2010); https://doi.org/10.1117/12.841177
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