Prediction of sensitivity thresholds in optoacoustic tomography

Daniel Razansky; John Baeten; Vasilis Ntziachristos

doi:10.1117/12.843256

23 February 2010 Prediction of sensitivity thresholds in optoacoustic tomography

Daniel Razansky, John Baeten, Vasilis Ntziachristos

Proceedings Volume 7564, Photons Plus Ultrasound: Imaging and Sensing 2010; 75640L (2010) https://doi.org/10.1117/12.843256
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

Since optoacoustic tomography is considered a high-resolution modality, determination of the absolute detection limit, as it relates to the sensitivity of biomarker detection is not straightforward. This is due to the fact that experimental determination of the sensitivity as a function of target size remains difficult since no established technique exists so far to reproducibly create very small targets containing well-defined concentrations of markers. We combine theoretical analysis with imaging results for large amounts of the marker and place the measured value on the appropriate parameter-dependent signal intensity curve. A performance estimate of the particular experimental system and the expected signal-to-noise-ratio for smaller amounts of markers can then be made.

Citation Download Citation

Daniel Razansky, John Baeten, and Vasilis Ntziachristos "Prediction of sensitivity thresholds in optoacoustic tomography", Proc. SPIE 7564, Photons Plus Ultrasound: Imaging and Sensing 2010, 75640L (23 February 2010); https://doi.org/10.1117/12.843256

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