25 February 2010 Improved contrast optoacoustic imaging of deep breast tumors using displacement-compensated averaging: phantom studies
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Abstract
For real-time optoacoustic imaging of the human body, a linear array transducer and reflection mode optical irradiation is usually preferred. Such a setup, however, results in significant image background, which prevents imaging structures at the ultimate depth limited only by the signal noise level. Therefore we previously proposed a method for image background reduction, based on displacement-compensated averaging (DCA) of image series obtained when the tissue sample under investigation is gradually deformed. Optoacoustic signals and background signals are differently affected by the deformation and can thus be distinguished. The proposed method has now been applied to imaging artificial tumors embedded inside breast phantoms. Optoacoustic images are acquired alternately with pulse-echo images using a combined optoacoustic/ echo-ultrasound device. Tissue deformation is accessed via speckle tracking in pulse echo images, and optoacoustic images are compensated for the local tissue displacement. In that way optoacoustic sources are highly correlated between subsequent images, while background is decorrelated and can therefore be reduced by averaging. We show that breast image contrast is strongly improved and detectability of embedded tumors significantly increased, using the DCA method.
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Michael Jaeger, Michael Jaeger, Stefan Preisser, Stefan Preisser, Michael Kitz, Michael Kitz, Martin Frenz, Martin Frenz, } "Improved contrast optoacoustic imaging of deep breast tumors using displacement-compensated averaging: phantom studies", Proc. SPIE 7564, Photons Plus Ultrasound: Imaging and Sensing 2010, 75640R (25 February 2010); doi: 10.1117/12.848028; https://doi.org/10.1117/12.848028
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