23 February 2010 Photoacoustic diagnosis of edema in rat burned skin
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Diagnosis of edema, abnormal accumulation of water in tissue, is important for managing various traumatic injuries and diseases. However, there is no established method for real-time, noninvasive monitoring of edema. In severe extensive burn injuries, edema develops both topically and systemically due to the increased permeability of blood vessels. In this study, we examined photoacoustic (PA) monitoring of edema formed in rat burn models. Deep dermal burn with a 20% total body surface area was made in the dorsal skin of rats. Burn and its adjacent nonburn tissues were irradiated with 6-ns light pulses at 1430 nm, which is one of the absorption peak wavelengths of water in the near infrared. The PA signal amplitude increased until 12 - 24 hr postburn, and thereafter it gradually decreased to its initial level; the latter phase (after 24 hr postburn) coincided with a diuretic phase in the rats. There was a significant correlation between the PA signal amplitudes and water contents in the tissue measured by wet/dry weight method. These findings demonstrate the validity of PA measurement for real-time, noninvasive monitoring of edema.
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Ken Yoshida, Ken Yoshida, Shunichi Sato, Shunichi Sato, Kosuke Hatanaka, Kosuke Hatanaka, Daizoh Saitoh, Daizoh Saitoh, Hiroshi Ashida, Hiroshi Ashida, Toshihisa Sakamoto, Toshihisa Sakamoto, Minoru Obara, Minoru Obara, } "Photoacoustic diagnosis of edema in rat burned skin", Proc. SPIE 7564, Photons Plus Ultrasound: Imaging and Sensing 2010, 75641C (23 February 2010); doi: 10.1117/12.841438; https://doi.org/10.1117/12.841438

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