23 February 2010 Optoacoustic 13C-breath test analyzer
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Abstract
The composition and concentration of exhaled volatile gases reflects the physical ability of a patient. Therefore, a breath analysis allows to recognize an infectious disease in an organ or even to identify a tumor. One of the most prominent breath tests is the 13C-urea-breath test, applied to ascertain the presence of the bacterium helicobacter pylori in the stomach wall as an indication of a gastric ulcer. In this contribution we present a new optical analyzer that employs a compact and simple set-up based on photoacoustic spectroscopy. It consists of two identical photoacoustic cells containing two breath samples, one taken before and one after capturing an isotope-marked substrate, where the most common isotope 12C is replaced to a large extent by 13C. The analyzer measures simultaneously the relative CO2 isotopologue concentrations in both samples by exciting the molecules on specially selected absorption lines with a semiconductor laser operating at a wavelength of 2.744 μm. For a reliable diagnosis changes of the 13CO2 concentration of 1% in the exhaled breath have to be detected at a concentration level of this isotope in the breath of about 500 ppm.
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Hermann Harde, Hermann Harde, Günther Helmrich, Günther Helmrich, Marcus Wolff, Marcus Wolff, } "Optoacoustic 13C-breath test analyzer", Proc. SPIE 7564, Photons Plus Ultrasound: Imaging and Sensing 2010, 75641E (23 February 2010); doi: 10.1117/12.841660; https://doi.org/10.1117/12.841660
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