Novel focused optoacoustic transducers for accurate monitoring of total hemoglobin concentration and oxyhemoglobin saturation: pre-clinical and clinical tests

Emanuel Särchen; Irina Petrova; Yuriy Petrov; Donald Prough; Walter Neu; Rinat O. Esenaliev

doi:10.1117/12.847084

25 February 2010 Novel focused optoacoustic transducers for accurate monitoring of total hemoglobin concentration and oxyhemoglobin saturation: pre-clinical and clinical tests

Emanuel Särchen, Irina Petrova, Yuriy Petrov, Donald Prough, Walter Neu, Rinat O. Esenaliev

Author Affiliations +

Proceedings Volume 7564, Photons Plus Ultrasound: Imaging and Sensing 2010; 75641I (2010) https://doi.org/10.1117/12.847084
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

We developed an optoacoustic technique for noninvasive, accurate, and continuous monitoring of total hemoglobin concentration and venous oxyhemoglobin saturation by probing specific blood vessels. In this work we report the development and tests of novel, focused optoacoustic transducers that provide blood vessel probing with sub-millimeter lateral resolution. The focused transducers were incorporated in our highly portable, laser diode-based optoacoustic monitoring system for pre-clinical and clinical tests. Our studies demonstrated that: 1) the focused transducer response is linearly dependent on blood total hemoglobin concentration with a high correlation coefficient; and 2) the sub-millimeter lateral resolution provided higher specificity of blood vessel probing, in particular, for smaller blood vessels such as the radial artery (diameter 2-3 mm).

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Emanuel Särchen, Irina Petrova, Yuriy Petrov, Donald Prough, Walter Neu, and Rinat O. Esenaliev "Novel focused optoacoustic transducers for accurate monitoring of total hemoglobin concentration and oxyhemoglobin saturation: pre-clinical and clinical tests", Proc. SPIE 7564, Photons Plus Ultrasound: Imaging and Sensing 2010, 75641I (25 February 2010); https://doi.org/10.1117/12.847084

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