23 February 2010 Continuous acquisition scanner for whole-body multispectral optoacoustic tomography
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Abstract
An essential problem dealing with three-dimensional optoacoustic imaging is the long data acquisition times associated with recording signals from multiple spatial projections, where signal averaging for each projection is applied to obtain satisfying signal-to-noise-ratio. This approach complicates acquisition and makes imaging challenging for most applications, especially for in vivo imaging and multispectral imaging. Instead we employ a herein introduced continuous data acquisition methodology that greatly shortens recording times over multiple projection angles and acquires high quality tomographic data without averaging. By this means a two dimensional image acquisition having 270 angular projections only takes about 9 seconds, while a full multispectral three dimensional image can normally take about 15 minutes to acquire with a single ultrasonic detector. The system performance is verified on tissue-mimicking phantoms containing known concentrations of fluorescent molecular agent as well as small animals.
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Rui Ma, Rui Ma, Vasilis Ntziachristos, Vasilis Ntziachristos, Daniel Razansky, Daniel Razansky, } "Continuous acquisition scanner for whole-body multispectral optoacoustic tomography", Proc. SPIE 7564, Photons Plus Ultrasound: Imaging and Sensing 2010, 756429 (23 February 2010); doi: 10.1117/12.842776; https://doi.org/10.1117/12.842776
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