Photoacoustic and ultrasound imaging contrast enhancement using a dual contrast agent

Katheryne Wilson; Kimberly Homan; Stanislav Emelianov

doi:10.1117/12.841424

23 February 2010 Photoacoustic and ultrasound imaging contrast enhancement using a dual contrast agent

Katheryne Wilson, Kimberly Homan, Stanislav Emelianov

Proceedings Volume 7564, Photons Plus Ultrasound: Imaging and Sensing 2010; 75642P (2010) https://doi.org/10.1117/12.841424
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

The complementary information provided by the ultrasound and photoacoustic imaging modalities has sparked their use in combination in recent years. We introduce a dual contrast agent capable of providing image contrast enhancement for both modalities simultaneously. The dual contrast agent is a small liquid perfluorocarbon droplet encased with bovine serum albumin and loaded with plasmonic nanoparticles. The plasmonic metal nanoparticles themselves act as a photoacoustic contrast agent. Furthermore, the perfluorocarbon droplet creates acoustic impedance mismatch between itself and the surrounding tissue, allowing it to act as an ultrasound contrast agent. Experiments demonstrating the performance of this dual contrast agent in ultrasound and photoacoustic imaging are presented. Differences in contrast mechanisms of the dual agent are highlighted, and finally, the applications for the agent are discussed.

Citation Download Citation

Katheryne Wilson, Kimberly Homan, and Stanislav Emelianov "Photoacoustic and ultrasound imaging contrast enhancement using a dual contrast agent", Proc. SPIE 7564, Photons Plus Ultrasound: Imaging and Sensing 2010, 75642P (23 February 2010); https://doi.org/10.1117/12.841424

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