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23 February 2010Combined photoacoustic and magneto-motive ultrasound imaging
Ultrasound imaging can provide excellent resolution at reasonable depths while retaining the advantages of being nonionizing,
cost-effective and portable. However, the contrast in ultrasound imaging is limited, and various ultrasoundbased
techniques such as photoacoustic (PA) and magneto-motive ultrasound (MMUS) imaging have been developed to
augment ultrasound imaging. Photoacoustic imaging enhances imaging contrast by visualizing the optical absorption of
either tissue or injected contrast agents (e.g., gold or silver nanoparticles). MMUS imaging enhances the sensitivity and
specificity of ultrasound based on the detection of magnetic nanoparticles perturbed by an external magnetic field. This
paper presents integrated magneto-photo-acoustic (MPA) imaging - a fusion of complementary ultrasound-based
imaging techniques. To demonstrate the feasibility of MPA imaging, porcine ex-vivo tissue experiments were performed
using a dual contrast (magnetic/plasmonic) agent. Spatially
co-registered and temporally consecutive ultrasound,
photoacoustic, and magneto-motive ultrasound images of the same
cross-section of tissue were obtained. Our ex-vivo
results indicate that magneto-photo-acoustic imaging can be used to detect magnetic/plasmonic nanoparticles with high
resolution, sensitivity and contrast. Therefore, our study suggests that magneto-photo-acoustic images can identify the
morphological properties, molecular information and complementary functional information of the tissue.
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Min Qu, Seungsoo Kim, Mohammad Mehrmohammadi, Srivalleesha Mallidi, Pratixa Joshi, Kimberly Homan, Yun-Sheng Chen, Stanislav Emelianov, "Combined photoacoustic and magneto-motive ultrasound imaging," Proc. SPIE 7564, Photons Plus Ultrasound: Imaging and Sensing 2010, 756433 (23 February 2010); https://doi.org/10.1117/12.842406